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COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies

Identifieur interne : 000942 ( Main/Exploration ); précédent : 000941; suivant : 000943

COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies

Auteurs : Gong Feng [République populaire de Chine] ; Kenneth I. Zheng [République populaire de Chine] ; Qin-Qin Yan [République populaire de Chine] ; Rafael S. Rios [République populaire de Chine] ; Giovanni Targher [Italie] ; Christopher D. Byrne [Royaume-Uni] ; Sven Van Poucke [Belgique] ; Wen-Yue Liu [République populaire de Chine] ; Ming-Hua Zheng [République populaire de Chine]

Source :

RBID : PMC:7132016

Abstract

Abstract

The outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has attracted increasing worldwide attention. Cases of liver damage or dysfunction (mainly characterized by moderately elevated serum aspartate aminotransferase levels) have been reported among patients with COVID-19. However, it is currently uncertain whether the COVID-19-related liver damage/dysfunction is due mainly to the viral infection per se or other coexisting conditions, such as the use of potentially hepatotoxic drugs and the coexistence of systemic inflammatory response, respiratory distress syndrome-induced hypoxia, and multiple organ dysfunction. Based on the current evidence from case reports and case series, this review article focuses on the demographic and clinical characteristics, potential mechanisms, and treatment options for COVID-19-related liver dysfunction. This review also describes the geographical and demographic distribution of COVID-19-related liver dysfunction, as well as possible underlying mechanisms linking COVID-19 to liver dysfunction, in order to facilitate future drug development, prevention, and control measures for COVID-19.


Url:
DOI: 10.14218/JCTH.2020.00018
PubMed: 32274342
PubMed Central: 7132016


Affiliations:


Links toward previous steps (curation, corpus...)


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<p>The outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has attracted increasing worldwide attention. Cases of liver damage or dysfunction (mainly characterized by moderately elevated serum aspartate aminotransferase levels) have been reported among patients with COVID-19. However, it is currently uncertain whether the COVID-19-related liver damage/dysfunction is due mainly to the viral infection per se or other coexisting conditions, such as the use of potentially hepatotoxic drugs and the coexistence of systemic inflammatory response, respiratory distress syndrome-induced hypoxia, and multiple organ dysfunction. Based on the current evidence from case reports and case series, this review article focuses on the demographic and clinical characteristics, potential mechanisms, and treatment options for COVID-19-related liver dysfunction. This review also describes the geographical and demographic distribution of COVID-19-related liver dysfunction, as well as possible underlying mechanisms linking COVID-19 to liver dysfunction, in order to facilitate future drug development, prevention, and control measures for COVID-19.</p>
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</TEI>
<affiliations>
<list>
<country>
<li>Belgique</li>
<li>Italie</li>
<li>Royaume-Uni</li>
<li>République populaire de Chine</li>
</country>
</list>
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<name sortKey="Feng, Gong" sort="Feng, Gong" uniqKey="Feng G" first="Gong" last="Feng">Gong Feng</name>
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<name sortKey="Liu, Wen Yue" sort="Liu, Wen Yue" uniqKey="Liu W" first="Wen-Yue" last="Liu">Wen-Yue Liu</name>
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<country name="Italie">
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<country name="Royaume-Uni">
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<country name="Belgique">
<noRegion>
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</country>
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</record>

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